Source: http://www.bbc.co.uk/news/health-19597856
Scientists playing with the unknown and with the human kind as objects.
A public consultation has been launched to discuss the ethics of using three people to create one baby.
The technique could be used to prevent debilitating and fatal
"mitochondrial" diseases, which are passed down only from mother to
child.
However, the resulting baby would contain genetic information from three people - two parents and a donor woman.
Ministers could change the law to make the technique legal after the results of the consultation are known.
About one in 200 children are born with faulty mitochondria -
the tiny power stations which provide energy to every cell in the body.
Most show little or no symptoms, but in the severest cases
the cells of the body are starved of energy. It can lead to muscle
weakness, blindness, heart failure and in some cases can be fatal.
Mitochondria are passed on from the mother's egg to the child
- the father does not pass on mitochondria through his sperm. The idea
to prevent this is to add a healthy woman's mitochondria into the mix.
Two main techniques have been shown to work in the laboratory, by using a donor embryo or a donor egg.
How do you make a baby from three people?
Step 1. Eggs from a mother with damaged
mitochondria and a donor with healthy mitochondria are collected. Step
2. The majority of the genetic material is removed from both eggs. Step
3. The mother's genetic material is inserted into the donor egg, which
can be fertilised by sperm.
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However, mitochondria contain their own
genes in their own set of DNA. It means any babies produced would
contain genetic material from three people. The vast majority would come
from the mother and father, but also mitochondrial DNA from the donor
woman.
This would be a permanent form of genetic modification, which would be passed down through the generations.
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It has huge potential significance
for society because for the first time children would be born with DNA
from three people - what has frequently been dubbed 'three parent IVF'.
Crucially that genetic alteration to what's known as the germ line would
be permanent, handed down from generation to generation”
It is one of the ethical considerations which will be discussed as part of the
Human Fertilisation and Embryology Authority's consultation.
The chair of the organisation, Prof Lisa Jardine, said: "It
is genetic modification of the egg - that is uncharted territory. Once
we have genetic modification we have to be sure we are damn happy."
She said it was a question of "balancing the desire to help
families have healthy children with the possible impact on the children
themselves and wider society".
Other ethical issues will also be considered, such as how
children born through these techniques feel, when they should be told,
the effect on the parents and the status of the donor woman - should she
be considered in the same way as an egg donor in IVF?
Hundreds of mitochondria in every cell provide energy
It is not the first time these issues have been discussed. A
report by the Nuffield Council on Bioethics
said the treatment was ethically OK, but the group Human Genetics Alert
said the procedure was unnecessary, dangerous and set a precedent for
genetically modified designer babies.
The consultation will run until 7 December and the conclusions will be presented to ministers next spring.
Research into the area is legal in the UK, but it cannot be used in patients.
However, treatments in IVF clinics will be years away even if
the public and ministers decide the techniques should go ahead. There
are still questions around safety which need to be addressed.
One of the pioneers of the methods, Prof Mary Herbert from
Newcastle University, said: "We are now undertaking experiments to test
the safety and efficacy of the new techniques.
"This work may take three to five years to complete."
